Can Hormone Imbalance Cause Depression

Can Hormone Imbalance Cause Depression?

Writen By: Sadia Mirza
Reviewed By: Huma Khan
Publish Date: December 10, 2023

Hormones play an important role in our overall well-being, affecting various aspects of our physical and mental health. Hormone imbalances have been linked to a range of health conditions. With this relation of hormonal imbalance to many conditions, there comes a question, Can hormone imbalance cause depression?

Hormone imbalances can contribute to the development of depression. As hormones play a great role in regulating mood and emotions, so when there is an imbalance in hormone levels, it disrupts the functioning of the brain and can result in depression

In this blog post, we will delve into this topic, Can hormone imbalance cause depression? We will explore the link between hormones and depression, hormonal imbalances in men and women, treatment options, and tips to prevent hormonal depression.

What Is Hormone Imbalance?

Hormone imbalance can be defined as when you have either too little or too many hormones in the blood. Hormones are chemical messengers that travel around the body through the bloodstream and tell your tissues and organs what to do. 

Causes of Hormone Imbalance

When hormones become imbalanced in the body, it leads to various problems, depending on the type of hormone that is affected. There are many causes of hormonal imbalance.

  • Medical Conditions

Medical conditions such as pituitary gland disorder, thyroid disorder, adrenal gland disorder, polycystic ovary syndrome (PCOS), and menopause can result in hormonal imbalances in your body. 

  • Medications

Many medications, such as birth control pills, steroids, and certain medications for cancer, can imbalance hormones in the body.

  • Lifestyle Factors

A diet that is high in processed foods and sugar, lack of sleep, and stress can contribute to hormonal imbalance.

  • Aging

As you age, your body naturally produces less of certain hormones.

  • Genetics

Some people are genetically inclined to develop hormonal imbalances.

Role of Hormones in the body’s functioning

Hormones play a great role in bodily functioning. They act as a communication system that controls and coordinates a vast array of vital functions. 

Some key roles that hormones play in our bodies are:

  • Growth hormones stimulate the growth of bones and muscles, cell repair, and overall development.
  • Thyroid hormones regulate metabolism, energy production, and growth.
  • Sex hormones are crucial for sexual development, puberty, and reproductive functions.
  • Insulin regulates how much glucose cells take up, which in turn affects blood sugar levels.
  • Glucagon stimulates the liver’s breakdown of glycogen, which increases blood sugar levels.
  • Estrogen and progesterone are hormones present in females that control menstrual cycle, ovulation, pregnancy, and breast development.
  • Testosterone is present in males that regulates sperm production, sex drive, muscle mass, and bone density.
  • Human chorionic gonadotropin (hCG) supports pregnancy by maintaining the corpus luteum and production of progesterone.
  • Serotonin plays a crucial role in mood regulation, sleep, and appetite.
  • Dopamine is involved in reward, motivation, and pleasure.
  • Norepinephrine affects alertness, focus, and stress response.
  • Cortisol is the primary stress hormone, responsible for managing the fight-or-flight response.
  • Hormones like aldosterone and antidiuretic hormone (ADH) control salt and water balance in the body.
  • Hormones like gastrin and secretin regulate stomach acid production and digestive enzyme secretion.
  • Hormones also play a role in immune response and inflammation.

Can Hormone Imbalance Affect Mental Health?

You might not realize it, but your hormones play a significant role in how you feel emotionally. Hormones act as messengers in your body, and when their balance is disrupted, it can influence your mental health.

Ever noticed how you feel different at certain times of the month? That’s the magic of hormones at play. Hormones like estrogen, progesterone, cortisol, and even thyroid hormones can affect how you feel.

Let’s break it down. When your hormones are doing their job smoothly, you usually feel great—balanced, happy, and able to tackle life. But when there’s an imbalance, say, during menstruation, menopause, or even due to stress, it can throw your emotions for a loop.

Hormone-Brain Connection

The “hormone-brain connection” refers to the relationship between the endocrine system and the central nervous system, specifically the brain. This complex network involves the interplay of hormones, neurotransmitters, and various brain regions to influence a wide range of physiological and psychological functions.

The hormone-brain connection is a two-way street: 

  1. The brain controls the release of hormones from various endocrine glands through the hypothalamus and pituitary glands.
  1. Hormones influence brain function by directly binding to receptors in the brain, and they influence the activity of neurons and the release of neurotransmitters, impacting mood, behavior, and cognition.

Your brain acts as the control tower for these hormones. It sends signals to various parts of your body to produce or regulate them. When this process goes wrong, your emotions can go on a rollercoaster ride.

An imbalance can impact your mental health more than you realize. It might contribute to mood swings, anxiety, depression, or even affect your ability to concentrate or sleep well.

Can Hormone Imbalance Cause Depression?

As hormones regulate various bodily functions, including mood, sleep, and stress response, when their levels are disrupted, it leads to negative effects on emotional and mental health, resulting in anxiety, stress, and hormonal depression.

So the connection between hormonal imbalance and depression exists because hormones directly influence the activity and production of neurotransmitters, which are responsible for carrying signals between brain cells. Thus, imbalances in hormones lead to symptoms of depression and anxiety, as well as other mental health disorders. 

Research suggests that hormonal imbalance is linked to the onset of depression, as hormones may be directly associated with the activation, inhibition, or modulation of the central nervous system.

Another research study shows that hormonal changes in women during the menstrual cycle, menopause, and postpartum result in depression. That is why women experience depression at twice the rate of men.

The answer to the question ‘Can Hormone Imbalance Cause Depression?’ can be found by looking at the various hormonal imbalances that occur in our bodies.

1. Dopamine

Dopamine is a neurotransmitter in the brain that plays a role in many functions in the body, such as mood, attention, memory, and motivation. It is part of the brain’s reward system. An imbalance in dopamine levels directly influences our mental health. A low level of dopamine results in anxiety, mood swings, hallucinations, low energy, and difficulty sleeping, leading to depression. 

Low levels of dopamine are also linked to health conditions like Parkinson’s disease and ADHD.

2. Cortisol

Cortisol, the stress hormone, also plays a vital role in the body’s “fight-or-flight” response. When cortisol levels are elevated, it can disrupt sleep, impair cognitive function, and worsen symptoms of anxiety and depression. 

Research says that fluctuations and imbalances in cortisol secretion result in psychiatric disorders such as depression and bipolar disorder. 

3. Serotonin

Serotonin plays a role in regulating your mood. An imbalance in serotonin levels affects your mental health in many ways.

Research says that an imbalance in serotonin levels is associated with mood disorders, anxiety, schizophrenia, autism, and attention deficit hyperactivity disorder (ADHD). 

4. Thyroid Hormones

Thyroid hormones regulate metabolism, energy levels, and mood. When the thyroid gland is underactive, it is often associated with symptoms of depression and fatigue, and this condition is known as hypothyroidism.

A 2022 Study shows that patients with hypothyroidism are at increased risk of developing depression

5. Adrenaline 

Adrenaline is released in response to stressful, exciting, dangerous, or threatening situations. When adrenaline is released, it is known as an ‘adrenaline rush’, as it makes the heart beat faster and increases blood flow to the brain and muscles. Low levels can lead to depression, attention deficit hyperactivity disorder (ADHD), lethargy (loss of energy), and difficulty concentrating.

6. Sex Hormones

The sex hormones estrogen, progesterone, and testosterone influence mood and emotional regulation differently in men and women. For example, fluctuations in estrogen levels during the menstrual cycle can contribute to symptoms of premenstrual dysphoric disorder (PMDD) resulting in a depressive mood.

Research study indicates that women are at twice the risk for anxiety and depression disorders due to fluctuations in their sex hormones. 

Several significant life events trigger hormonal changes, which can have a great impact on mental health and can cause hormonal depression. During early pregnancy, HCG (Human chorionic gonadotropin) levels rise rapidly, causing mood swings, and an increase in estrogen and progesterone levels during pregnancy also results in prenatal depression.

Fluctuations in melatonin and sleep hormones can lead to insomnia, fatigue, and difficulty concentrating, impacting mood and overall well-being.

So, can hormone imbalance cause depression? Yes, it can. We now know how changes in hormones affect brain chemistry and lead to depression. So, the connection is clear – when our hormones are not in harmony, it can influence our mental health. Understanding this helps us see how major life events can impact our mood. So next time, if you’re feeling down, remember that it might be just these hormones at play that influence how you feel.

Hormone Imbalance in Men vs Women

While the symptoms of hormone imbalances can overlap between men and women, there are key distinctions in the specific hormones affected and the manifestation of their imbalances.


Testosterone: The main hormone involved in male sex, testosterone affects many aspects of a person’s health, including sex drive, muscle mass, bone density, and growth of facial and body hair. Men with low testosterone levels may experience:

  • Erectile dysfunction
  • Loss of muscle mass and strength
  • Increased body fat
  • Fatigue and decreased energy
  • Depression and irritability

Estrogen: Although primarily considered a female hormone, men also produce small amounts of estrogen. High estrogen levels in men can lead to:

  • Gynecomastia (breast enlargement)
  • Decreased libido
  • Fatigue
  • Difficulty concentrating


Estrogen and progesterone: These are the primary female sex hormones responsible for regulating the menstrual cycle, ovulation, fertility, and other functions. Imbalances in these hormones can lead to:

  • Irregular periods
  • Premenstrual syndrome (PMS)
  • Infertility
  • Hot flashes and night sweats
  • Mood swings and depression
  • Increased risk of osteoporosis

Thyroid hormones: These hormones regulate metabolism, energy levels, and body temperature. Imbalances in thyroid hormones, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid), can affect both men and women, leading to:

  • Fatigue
  • Weight gain or loss
  • Changes in mood
  • Changes in sleep patterns
  • Sensitivity to cold or heat
  • Hair loss or thinning

Hormone-Related Depression

As hormones play a great role in regulating bodily function, changes and imbalances in their levels can disturb mood and emotional well-being.  Symptoms of hormonal depression include: 

Emotional Symptoms

  • Overwhelming sadness.
  • Stress or Anxiety.
  • Mood swings.
  • Confusion and chaos.
  • Irritability and frustration.
  • Reduced sex drive.
  • Trouble concentrating.

Physical Symptoms

  • Fatigue.
  • Weakness and muscle pain.
  • Frequent urination.
  • Sensitivity to hot or cold.
  • Irregular heartbeat.
  • Constipation.
  • Diarrhea.
  • Increased sweating.
  • Weight changes.
  • Trouble sleeping.
  • Memory issues or brain fog.

Symptoms Related to Women

Diagnosing Hormonal Imbalance

Doctors diagnose hormonal imbalances by starting with a routine medical examination, inquiring about your symptoms, and recommending blood or urine tests as the endocrine glands release hormones directly into your bloodstream, a pelvic exam, ultrasound, and sometimes other tests such as X-rays, magnetic resonance imaging (MRIs), biopsies, or thyroid scans if they are needed according to the situation.


There are many treatment options available for hormonal depression. Let’s discuss them. 

Hormone Therapy

  • Estrogen Therapy:

It may help with major or minor depression and depressive symptoms linked to menopause.

Evidence is inconclusive due to variations in studies and the potential for placebo effects.

  • Thyroid Hormone Therapy:

T3 is used more often than T4 for depression treatment. It can be used as monotherapy or in combination with other treatments.

  • Other Hormone Therapies:

Progesterone, testosterone, and other hormones may be used depending on individual needs and imbalances.


  • Antidepressants:

First-line treatment for many types of depression, including hormone-related depression is antidepressants.

Different types and dosages available to find the best fit and it may be used in combination with hormone therapy.

  • Anti-anxiety medications:

Anti anxiety medications may be helpful for individuals with co-occurring anxiety disorders.

  • Other medications:

Medications targeting specific hormone imbalances or related conditions may be used.

Lifestyle Strategies

  • Exercise: Regular physical activity can improve mood and reduce depression symptoms.
  • Diet: Eating a healthy diet rich in fruits, vegetables, and whole grains can support mental health.
  • Sleep: Getting enough quality sleep is crucial for managing depression.

Support Groups

Connecting with others who understand the challenges of hormone-related depression can provide valuable support and encouragement.

How To Prevent Hormonal Depression

While completely preventing hormonal depression might be challenging, several preventive tips can help manage symptoms and reduce the severity of hormonal depression.

  • Life style changes such as moderate-intensity exercising regularly helps regulate hormones, boost mood, and reduce stress.
  • Eating a diet rich in fruits, vegetables, whole grains, and lean protein can prevent hormonal imbalance and depression. Avoid processed foods, sugary drinks, and excessive caffeine, all of which can worsen symptoms.
  • Establish a regular sleep schedule and create a relaxing bedtime routine because poor sleep disrupts hormone balance and exacerbates mood swings. 
  • Stress can trigger hormonal imbalances and worsen depression. Practice relaxation techniques like yoga, meditation, or deep breathing exercises to manage stress levels.
  • Engage in activities you enjoy. Strong social connections provide support and reduce feelings of isolation, which can contribute to depression.
  • Getting regular exposure to sunlight helps control the body’s natural circadian rhythm and can improve mood and energy levels.
  • Taking Calcium and Vitamin D may help alleviate PMS symptoms and improve mood. Consult your doctor to determine the appropriate dosage.
  • Practice mindfulness and self-compassion to prevent hormonal depression.


The connection between hormone imbalance and depression is complex and multifaceted. While reading about this topic, ‘Can hormone imbalance cause depression?’ We came to know that hormones play a significant role in regulating mood and emotions and contribute to depression. 

Hormonal imbalances are common during pregnancy, menopause, puberty, menstruation, and aging but many people experience continual irregular hormonal imbalance.

However, it is crucial to consult with a medical professional to determine the underlying cause of depression and explore the appropriate treatment options. Remember, everyone’s experience is unique, and seeking professional guidance is key to finding the right solutions for your individual needs.

Additional Resources

There are many sources and organizations that can help you with hormonal depression. Some of them are included below:

National Institute of Mental Health (NIMH)

American Psychological Association (APA)

Johns Hopkins Medicine

Endocrine Society


Which hormone is responsible for depression?

Several hormones can contribute to depression such as serotonin, dopamine, Norepinephrine, Estrogen and Progesterone, Testosterone and Thyroid hormones. Cortisol (stress hormone), melatonin (sleep hormone), and DHEA (precursor to other hormones) may also play a role in mood regulation and depression.

How do you fix hormonal imbalances?

Hormonal imbalance can be fixed by hormone therapy, medications and certain life style changes.

What are the 4 main causes of depression?

Four major contributors that cause depression are:

1. Biological Factors 

  • Imbalances in neurotransmitters.
  • Genetics.
  • Medical conditions.

2. Psychological Factors

  • Personality traits.
  • Negative thought patterns.
  • Unhealthy coping mechanisms like substance abuse and social withdrawal.

3. Social Factors

  • Stressful life events.
  • Social isolation. 
  • Early childhood experiences. 

4. Environmental Factors

  • Socioeconomic status.
  • Diet and nutrition.
  • Sleep disturbances.

Which pills can balance hormones?

Pills like Metformin and Levothyroxine can balance hormones.

Different pills target specific hormones or imbalances, and the best option for you depends on your individual needs and diagnosis.

Do antidepressants balance hormones?

Overall, antidepressants do not directly “balance” hormones. Their primary function is to affect brain chemicals like serotonin and norepinephrine, which can indirectly influence hormonal balance.

What antidepressants are good for hormonal imbalances?

Lexapro helps in hormonal imbalance as it increases the production of serotonin hormone and brings back a happy mood.

Fluoxetine regulars estrogen levels.

Can hormone pills help with depression?

Yes, hormone pills help with depression according to the research as it shows that the number of hormones and hormone-manipulating compounds have been evaluated as monotherapies or adjunctive treatments for major depression.