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Can depression cause schizophrenia

Can Depression Cause Schizophrenia?

Writen By: Sana Ihsan
Reviewed By: Huma Khan
Publish Date: January 6, 2024

In the world of mental health, something interesting has caught our attention. We have noticed cases where people who go through depression sometimes also have strange experiences, like hearing voices or believing things that don’t really make any sense. This led us to think, Can depression cause schizophrenia? It’s a question that has made us curious, and we are going to find out how depression and schizophrenia might be connected.

Both schizophrenia and depression are two distinct mental disorders that carry a world of emotions and challenges. Schizophrenia can make you see and hear things that others don’t. On the other hand, depression greatly affects your mood, making you feel sad and hopeless all the time and unable to find pleasure in anything. But are these two distinct disorders connected in any way? Or Can one lead to the other and if so, how?

So stay with us till the end because, in this blog post, we are going to answer this interesting question, “Can depression cause schizophrenia?”. We will unveil the complex connection between schizophrenia and depression with the help of the latest research findings. So this blog is not only going to help you find answers to your questions but also to provide you with valuable resources such as organizations where you can seek therapy and self-help books that can help you on your journey to better mental health.  

What Is Depression? 

Depression is a mental health issue where someone consistently feels very sad and loses interest or joy in things they once enjoyed. It’s more than just normal mood swings and can greatly affect daily life.

Common Symptoms

The following are the most common symptoms of depression:

Types of Depression

The following are some types of depression:

1. Major Depressive Disorder (MDD)

This is the most prevalent type, with severe depression symptoms that persist for a minimum of two weeks.

2. Persistent Depressive Disorder (PDD)

Chronic depression lasts for two years or more, with less severe symptoms.

3. Bipolar Depression

It involves depressive episodes alternating with periods of mania or hypomania.

4. Seasonal Affective Disorder (SAD)

Depression occurs seasonally, often in the winter months in which there is fewer hours of sunlight.

5. Psychotic Depression

It combines severe depressive symptoms with psychosis, such as delusions or hallucinations.

6. Postpartum Depression

Affecting some individuals after childbirth, it is it is it is characterized by intense feelings of sadness and anxiety.

7. Atypical Depression

Depression, with distinct features like mood reactivity, increased appetite/sleep, leaden limbs, and rejection sensitivity, often affects younger individuals.


Depression often coexists with other mental health disorders, a phenomenon known as comorbidity. It can occur alongside anxiety disorders, substance abuse, eating disorders, or attention-deficit/hyperactivity disorder (ADHD), complicating the overall mental health picture. Understanding these interconnections is crucial for comprehensive treatment and support.

What Is Schizophrenia? 

Schizophrenia is a serious mental health condition that distorts your reality and messes with how you think, feel, and act. It makes it hard for you to tell what’s real and what’s not. This complicated issue shows up in different ways, like seeing things that aren’t there, having jumbled thoughts, and having mixed feelings. People with schizophrenia may find it tough to understand the world, affecting how they live each day and connect with others. Sorting out this challenge requires a careful approach to figuring out what’s going on and finding the best ways to help.

This 2010 study says that figuring out why people get schizophrenia is really tricky because it involves lots of genes and environmental factors. It suggests that understanding how the brain develops abnormally in schizophrenia might be the key to preventing it.

Key Characteristics of Schizophrenia

Some symptoms of schizophrenia include the following:

  • Hallucinations: Sensing things that aren’t present, commonly hearing voices.
  • Delusions: Strongly held false beliefs, like being persecuted or possessing special powers.
  • Disorganized Thinking: Difficulty organizing thoughts leads to unclear or jumbled speech.
  • Disorganized or Abnormal Motor Behavior: Unpredictable movements, ranging from agitation to remaining immobile for extended periods.
  • Negative Symptoms: Reduced emotional expression, social withdrawal, and difficulty experiencing pleasure.
  • Cognitive Impairment: Challenges in memory, attention, and executive function.


According to a research paper from 2023, the global prevalence of schizophrenia increased by 65% from 1990 to 2019. The study estimated that there were 23.6 million people living with schizophrenia worldwide in 2019.

The study’s authors found that the most significant increases in schizophrenia prevalence occurred in low- and middle-income countries and highlighted the need for increased investment in mental healthcare in these countries.

Impact of Schizophrenia on Individuals

The impact of schizophrenia on individuals can be:

  • Difficulty connecting with others, leading to isolation.
  • Memory issues, trouble focusing, and difficulty making decisions.
  • Fluctuations in mood, often leading to inappropriate emotional responses.
  • Difficulty holding down a job or consistently attending school due to symptoms.
  • Struggles with managing daily activities, such as self-care and household tasks.
  • Difficulty handling finances, resulting in increased dependence on others or financial instability.
  • Encountering societal stigma, which may lead to discrimination and hinder social integration.
  • Impact on family relationships due to the challenges of understanding and coping with the condition.
  • Disregard for physical health, including poor diet, lack of exercise, and neglect of medical needs.
  • Higher susceptibility to substance misuse as a coping mechanism.

Related Disorders in the Schizophrenia Spectrum

Other disorders within the spectrum share similarities with schizophrenia, primarily distinguished by the duration of symptoms and potential co-occurrence with mood disorders.

Schizophreniform Disorder

It’s like early schizophrenia, lasting from 1 to 6 months. Sometimes the symptoms just vanish without turning into full schizophrenia.

Schizoaffective Disorder

It mixes psychotic symptoms with depression or bipolar disorder. These symptoms might occur even when your mood seems fine. It’s a rare, lasting condition.

Now that we have explained both depression and schizophrenia, let’s move forward and figure out, Can depression cause schizophrenia? 

Can Depression Cause Schizophrenia? Exploring the link 

The connection between depression and schizophrenia is complicated. Even though they are different mental health issues, some people may have both at the same time, which is called comorbidity. Dealing with both can be tricky because their symptoms can overlap. 

Now, you might be asking, “Can depression cause schizophrenia?” The answer is yes. Research studies have shown that, in some situations, depression can be a factor in causing schizophrenia.

A study by Upthegrove, Marwaha, and Birchwood in 2017 found that, in some cases, depression could be the starting point for schizophrenia, as a subset of participants reported experiencing depressive symptoms before the onset of psychotic symptoms. 

Another 2009 study by Lichtenstein et al. found that individuals with a history of depression were twice as likely to develop schizophrenia compared to those without depression. This suggests a potential causal link.

Even a meta-analysis by Upthegrove et al. (2016) provides stronger evidence by aggregating data from multiple studies. It demonstrated that depression is a risk factor for developing psychosis, including schizophrenia.

So, there’s a link, but it’s a puzzle involving genes, environment, and the brain. We still need more research to figure out this depression and schizophrenia connection.

Factors Associated with Depression Leading to Schizophrenia 

In order to provide a more thorough response to the question, “Can depression cause schizophrenia?” Let us examine the following depression-related factors that may contribute to schizophrenia: 

1. Genetic Factors

Research suggests that there may be a hereditary component to both depression and schizophrenia. Certain genes have been associated in studies with a higher prevalence of both disorders. 

To give you an example, Sullivan et al.’s (2012) study found that particular genetic variations were linked to an increased risk of both depression and schizophrenia. These genetic factors may be responsible for common flaws and increase the likelihood that schizophrenia will result from depression.

2. Neurobiological Changes

Depression can cause changes in brain structure and function, which could potentially influence the development of schizophrenia. Abnormalities in neural circuits, neurotransmitter systems, or alterations in the prefrontal cortex may be factors that create a neurobiological environment conducive to the onset of schizophrenia.

This 2022 study also confirms the fact that neurobiological factors, including genetic influences and changes in grey matter in the brain, can contribute to the development of schizophrenia.

3. Chemical Imbalances

When the chemicals in our brain, like serotonin and dopamine, are not balanced, it can lead to problems like depression and schizophrenia. If these imbalances last a long time during periods of depression, they might cause more changes in the brain chemicals, making it more likely for someone to develop schizophrenia.

In a study from 2014, it was found that these imbalances in chemicals like dopamine, glutamate, GABA, acetylcholine, and serotonin can play a role in the development of schizophrenia.

4. Stress and Trauma

Long-lasting stress and traumatic experiences that make you very sad might play a role in causing depression. These tough situations could mix with things in your genes, affecting how your brain works and leading to schizophrenia.

A study in 2019 also shows that hard experiences during childhood can make you more likely to get schizophrenia. It talks about how stress, especially from tough times in childhood, works with things already in your brain, causing symptoms of schizophrenia.

5. Inflammation and Immune System Dysregulation

Researchers are investigating how inflammation and problems with the immune system affect both physical and mental health, including depression and schizophrenia. They believe that chronic inflammation brought on by depression may disrupt immune system processes and raise the risk of schizophrenia. 

Although the exact link between the immune system and the brain is complex and being explored, a recent study in 2022 suggests that problems in the immune system and brain inflammation may contribute to the development of schizophrenia.

6. Cognitive Impairments

Ongoing issues with thinking, memory, and decision-making seen in depression could play a role in moving towards schizophrenia. These challenges in how the brain works may team up with other factors, making it tough and complex, leading to the development of psychotic symptoms. For instance, trouble with attention and memory might make it harder to ignore unimportant details and stay focused, possibly raising the chances of experiencing things like hallucinations and delusions

So, this exploration provides clarity and answers the question, ‘Can depression cause schizophrenia?’ The discussion, research, and factors involved show a strong connection between depression and schizophrenia. However, it’s essential to note that depression cannot be considered the main cause of schizophrenia. While some individuals with schizophrenia might first experience depression, this is not true for everyone. 

Can Schizophrenia Cause Depression? 

After knowing the answer to Can depression cause schizophrenia? Now, let’s flip the coin. There’s a thought that having schizophrenia might sometimes make someone feel down or depressed. So, can schizophrenia cause depression? Scientists have looked into this, too. They’ve studied whether people diagnosed with schizophrenia might later struggle with depression.

This 2018 research challenges the idea that depression and schizophrenia are unrelated, proposing a connection. It suggests that schizophrenia might contribute to the occurrence of depression, challenging traditional views.

According to the 2020 study, depression significantly affects schizophrenia patients, reducing quality of life and increasing suicide risk. About 25% of people with schizophrenia experience major depression at a given time, with around 60% facing it at some point in their lives.

Another 2021 study also found that 24.9% of patients with schizophrenia experienced depression. It further suggests screening and timely management of depressive symptoms are crucial to reducing the burden of schizophrenia.

So the above discussion shows that the link between depression and schizophrenia is complicated and likely involves a bidirectional interaction. Depression can be a risk factor for schizophrenia, and vice versa.

Schizophrenia may lead to depression due to the following reasons:

  1. Social Isolation and Stigma

The social challenges and stigma associated with schizophrenia can lead to social isolation, limited opportunities, and strained interpersonal relationships. These factors contribute to a higher risk of developing depressive symptoms in individuals with schizophrenia.

  1. Cognitive Impairments and Functional Decline

The cognitive impairments often present in schizophrenia, including difficulties in concentration and decision-making, can hinder daily functioning. Persistent functional decline and the struggle to meet personal or societal expectations may contribute to feelings of inadequacy and despair, leading to depressive symptoms.

  1. Medication Side Effects

Antipsychotic medications, commonly prescribed for schizophrenia, can have side effects, including mood disturbances. Some individuals may experience drug-induced depression or other mood-related complications, adding an additional layer of complexity to the mental health profile of those with schizophrenia.

  1. Chronic Nature of Schizophrenia

The chronic nature of schizophrenia, characterized by recurring episodes and long-term management, can take a toll on an individual’s resilience. The continuous effort required to cope with the symptoms and challenges of schizophrenia may contribute to a sense of hopelessness and, subsequently, depressive feelings.

  1. Neurobiological Factors

Disruptions in neurotransmitter systems and neurobiological changes associated with schizophrenia may also play a role in the development of depression. The intricate interplay between neurotransmitters and brain structures involved in both disorders can contribute to the co-occurrence of depressive symptoms in individuals with schizophrenia.

Understanding the bidirectional relationship between schizophrenia and depression is crucial for providing comprehensive and effective mental health care. Tailoring interventions to address both aspects of these complex conditions can contribute to improved overall well-being for individuals facing these challenges.

Co-occurrence of Depression and Schizophrenia

Although they are separate mental illnesses, schizophrenia and depression frequently coexist in people, creating a difficult and complex condition. According to a 2009 study by Buckley et al., approximately 50% of individuals with schizophrenia also exhibit symptoms of depression. Individuals with comorbid depression were found to have a poorer prognosis and quality of life compared to those with schizophrenia alone.

According to Buckley and colleagues (2011), co-occurring depression and schizophrenia were associated with poorer treatment outcomes and a higher risk of suicide.

This shows that the co-occurrence of these two conditions may significantly impact a person’s general well-being and capacity. People who display symptoms of schizophrenia or depression require a specialist’s guidance and care. To properly manage these conditions, mental health specialists can offer the proper diagnosis, treatment, and advice.  

Common Signs and Symptoms of Co-Occurring Depression and Schizophrenia

The following are the common signs and symptoms of the co-occurrence of schizophrenia and depression.

  • Severe Mood Swings: Fluctuations between deep sadness and distorted thoughts.
  • Social Isolation: Difficulty connecting with others due to both depressive withdrawal and schizophrenia-related challenges.
  • Impaired Cognitive Function: Memory issues, trouble concentrating, and disorganised thinking.
  • Sleep Disturbances: Insomnia or oversleeping.
  • Hallucinations and Delusions: Experiencing both depressive thoughts and distorted perceptions.
  • Emotional Flattening: Limited range of emotional expression.
  • Difficulty in Daily Functioning: Struggles with everyday tasks due to a combination of depressive and schizophrenic symptoms.

Understanding and addressing the co-occurrence of depression and schizophrenia is crucial for developing effective treatment strategies that target both aspects of the individual’s mental health.

Challenges in Diagnosing Co-Occurring Depression and Schizophrenia

The following challenges are usually faced by healthcare professionals in diagnosing schizophrenia and depression when they are co-existing: 

  • Cognitive Impairments

Both depression and schizophrenia can affect cognitive function, making it challenging for individuals to accurately convey their experiences.

  • Atypical Presentations

Some individuals may exhibit atypical symptoms, deviating from typical diagnostic criteria.

  • Mood Fluctuations

The varying nature of mood in both conditions adds complexity to diagnosis, as symptoms may overlap or change rapidly.

  • Physical Health Disregard

Both disorders may lead to neglect of physical health, and this could contribute to a range of symptoms further complicating diagnosis.

These difficulties highlight the necessity of a thorough assessment by medical experts. 

Treatment Options 

The following are some of the useful treatment options for this condition:

Therapeutic Approaches

The therapy approaches for this condition are as follows:

  • Cognitive-Behavioral Therapy (CBT)

 Targets negative thought patterns, helping individuals manage distorted thinking associated with both depression and schizophrenia.

  • Supportive Therapy

Offers a safe space for individuals to express their feelings, fostering a supportive environment for coping with emotional challenges.

  • Family Therapy

Involves family members in the treatment process, enhancing understanding and support for the individual.

Medication Management

The following are the medications that can help to treat both depression and schizophrenia together:

  • Antidepressants

 Address depressive symptoms by regulating mood-enhancing neurotransmitters.

  • Antipsychotics

Manage the hallucinations, delusions, and disorganized thinking associated with schizophrenia.

  • Mood Stabilizers

May be prescribed in cases of mood swings or schizoaffective features.

  • Anxiolytics

Assist in managing anxiety symptoms that can co-occur with depression and schizophrenia.

Electroconvulsive Therapy (ECT)

 ECT may be considered for severe and treatment-resistant cases, particularly when depressive symptoms are prominent.

Community Support Programs

Some support programs that can help are: 

  • Vocational Training

 Aids in developing skills for employment, addressing challenges in job retention often seen in co-occurring disorders.

  • Social Skills Training

Helps individuals enhance interpersonal skills and manage social interactions.

  • Peer Support Groups

Offer a sense of community and understanding, reducing social isolation.

Lifestyle Changes

Some lifestyle changes that can help are:

  • Exercise and Nutrition

Regular physical activity and a balanced diet contribute to overall well-being and can positively impact mental health.

  • Sleep Hygiene

Establishing healthy sleep habits is crucial for managing symptoms associated with both depression and schizophrenia.

  • Hydration

Maintaining adequate hydration is crucial for overall health, including cognitive function. Proper water intake supports physical well-being and can positively influence mental health in individuals managing depression and schizophrenia.

  • Vitamin D and Omega-3 Fatty Acids

Including foods rich in vitamin D and omega-3 fatty acids, or considering supplements, can be beneficial for mental health. These nutrients are linked to brain function and may contribute to improved mood and cognitive function in individuals with depression and schizophrenia.

A personalised and integrated treatment approach that combines therapy, medication, and support services is essential for effectively managing co-occurring depression and schizophrenia. The involvement of mental health professionals, support networks, and a focus on overall well-being enhances the chances of successful long-term outcomes.

Coping Strategies for Depression and Schizophrenia

The following coping strategies can help to overcome depression and schizophrenia:

1. Establish a Routine

 Creating a structured daily routine provides stability, helping individuals manage symptoms and maintain a sense of control.

2. Set Realistic Goals

 Breaking larger tasks into smaller, achievable goals reduces feelings of overwhelm and fosters a sense of accomplishment.

3. Seek Social Support

Building a strong support network of friends, family, or support groups can provide understanding and encouragement during challenging times.

4. Mindfulness and Relaxation Techniques

Incorporating mindfulness practices, deep breathing, or guided relaxation can help manage stress and improve overall well-being.

5. Maintain Physical Health

Regular exercise and a balanced diet contribute to both physical and mental health, promoting a positive outlook.

6. Limit Substance Use

Avoiding or moderating substance use, including alcohol and recreational drugs, is crucial for managing symptoms and preventing exacerbation.

7. Journaling

Writing down thoughts and feelings can be a therapeutic outlet, allowing individuals to reflect on their experiences and gain insights into their emotions.

8. Medication Adherence

For those prescribed medication, consistent adherence to the prescribed regimen is vital. Any concerns or side effects should be discussed with healthcare providers.

9. Educate Yourself

Understanding one’s condition helps in developing effective coping strategies. Learning about depression and schizophrenia can empower individuals to navigate their challenges more effectively.

10. Create a Safe Space

Designating a calming and safe environment at home provides a retreat during times of distress.

It’s essential for individuals with co-occurring depression and schizophrenia to tailor coping strategies to their unique needs and consult with mental health professionals to develop a comprehensive plan for managing their conditions.

This 2017 study asked people who care for someone with schizophrenia about what they think is important for the person’s treatment. Carers mentioned things like safety, understanding the illness, and finding relief from fear. The study suggests we should use these insights to create measures that consider all the important aspects of treatment for individuals with schizophrenia.

Self-Help Books

The following are some of the self-help books about schizophrenia and depression. These books might answer the question” Can depression cause schizophrenia” for you.

  1. Schizophrenia and Manic Depressive Disorder by E. Fuller Torrey 

This book explores the complexities of schizophrenia and manic depressive disorder, offering insights into their nature.

  1. Depression in Schizophrenia by M.D. Delisi 

This book focuses on the intricate relationship between depression and schizophrenia, delving into the nuances of coexisting symptoms.

  1. Neurochemistry of Schizophrenia and Depression by Aman U. Khan 

This book delves into the neurochemical aspects, unraveling the intricate connections between neurotransmitters and the manifestations of schizophrenia and depression.

Therapy-Providing Organisations

Here are some of the online platforms that provide therapy and support that can help you overcome your depression and schizophrenia.


HelpGuide is an organisation that provides helpful information and resources to support mental health and well-being.

SAMHSA is an organisation focused on improving mental health services and promoting recovery from mental illnesses and substance use disorders in the United States.

National Alliance on Mental Illness( NAMI) 

NAMI is an organisation dedicated to providing support, education, and advocacy for individuals and families affected by mental health conditions.


Online therapy with licensed therapists and a variety of self-help resources.


 Online therapy with licensed therapists, group therapy, and psychiatry services.


Online psychiatry with medication management for mental health conditions.


In conclusion, we’ve delved into the connection between feeling really sad or depressed and something called schizophrenia. We explored the question, ‘Can depression cause schizophrenia?’ to learn more about our minds. While these two conditions don’t directly cause each other, there’s evidence that they can coexist and significantly impact mental health. Though research suggests a strong link between depression and schizophrenia, but it doesn’t prove that depression always leads to schizophrenia. Other things, like shared genes or specific situations, could also be part of the picture. It’s crucial to be aware of the warning signs and symptoms of both schizophrenia and depression and to seek professional assistance when needed.

Mental health is complex, and the right care and support can make a significant difference in well-being. Let’s strive to build a culture that values mental health and provides help to those in need. Remember the saying, ‘It’s okay to not be okay, but it’s not okay to stay that way.’ Our journey is about supporting each other, understanding, and working together to keep our minds healthy.

Frequently Asked Questions

Here are some of the frequently asked questions about schizophrenia and depression.

  1. What is the leading cause of schizophrenia?

Schizophrenia doesn’t have a single cause; a combination of genetic, biological, and environmental factors contributes. Genetics play a role, as individuals with a family history of schizophrenia have a higher risk. Neurochemical imbalances and prenatal exposures may also influence its development. High-stress environments during childhood and certain drug use can contribute.

  1. Can you get schizophrenia from anxiety?

Anxiety itself doesn’t directly cause schizophrenia. However, prolonged and severe anxiety can contribute to mental health challenges. While anxiety and schizophrenia share some symptoms, they are distinct disorders. If you have concerns, consulting with a mental health professional is crucial for an accurate diagnosis and appropriate guidance.

  1. Am I schizophrenic or depressed?

Only a qualified mental health professional can provide a precise diagnosis. Schizophrenia and depression are different conditions, but they can coexist. Schizophrenia involves disruptions in thought processes, hallucinations, and delusions, while depression is characterised by persistent feelings of sadness. If you’re experiencing symptoms, seeking professional help is essential for an accurate diagnosis and tailored treatment.

  1. What does a psychotic break look like?

A psychotic break, or a psychotic episode, involves a severe disruption in a person’s thoughts and perceptions. Symptoms may include hallucinations, delusions, disorganised thinking, and impaired functioning. It’s crucial to seek immediate professional help if you or someone else experiences these symptoms to receive appropriate care.

  1. Can overthinking cause schizophrenia?

Overthinking alone doesn’t cause schizophrenia, but excessive stress and anxiety can contribute to mental health challenges. Genetic predisposition and environmental factors also play crucial roles in the development of schizophrenia. If you have concerns about your mental health, consulting with a mental health professional can provide clarity and guidance.

  1. What is burnt out schizophrenia?

Burnout schizophrenia refers to a state where symptoms become less intense or pronounced, often occurring in older individuals with chronic schizophrenia. It refers to an outdated concept where symptoms of schizophrenia are believed to diminish with age. However, schizophrenia is a lifelong condition, and symptoms can fluctuate but usually require ongoing management. Consulting with a mental health professional can provide accurate information about the condition and appropriate interventions.